Myeloproliferative neoplasms (MY-ah-lo-pro-LIF-er-uh-tiv NEE-o-plaz-uhms), or MPNs, are a group of rare, chronic blood cancers in which a person’s bone marrow does not function properly. Bone marrow is a spongy tissue where blood cells are primarily made. In people with MPNs there is an abnormal production of these blood cells. This can cause a host of symptoms and complications.

Once you have been diagnosed with an MPN, it is important to know the state of your condition and to get the appropriate care. Be sure to schedule regular visits and conversations with your healthcare team.

What Are Myeloproliferative Neoplasms (MPNs)?

MPNs are rare, chronic blood cancers. Chronic conditions last for a long period of time and may never go away. MPNs can be classified based on the presence or absence of a chromosomal abnormality called the Philadelphia chromosome. There are several types of Philadelphia chromosome–negative MPNs, which are:

Each type of MPN is characterized by a particular pattern of abnormal blood cell production that usually impacts one blood cell type more than the others.

Fast Facts About Myeloproliferative Neoplasms (MPNs)

  • MPNs are progressive conditions, meaning that they worsen over time.
  • MPNs can affect people at any age, but they are more common in older adults.
  • Mutations, or changes in certain genes, are thought to be a major cause of what are known as Philadelphia chromosome–negative MPNs, or "classical" MPNs. Even people who do not have these mutations may have MPNs.

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