Sorry, you need to enable JavaScript to visit this website.

What Is MF?

Myelofibrosis (MF) is a rare, chronic blood cancer. It can also "progress," or get worse over time. For example, new symptoms may appear or existing symptoms may get worse.

MF is part of a group of diseases called "myeloproliferative neoplasms," or MPNs. Healthcare Professionals sometimes call this condition a bone marrow cancer or blood cancer. Bone marrow is a spongy tissue inside of the bone, and is the primary place where blood cells are made. People with MF have a defect in their bone marrow that results in an abnormal production of blood cells, causing scar tissue to form.

MF can result from a progression of other bone marrow diseases or it can occur on its own. This is known as primary myelofibrosis.

Learn more about what causes MF.

Image of Louise an MF Patient

Don't be afraid to talk to your doctor. You have to be proactive. You need to inform them what's going on in your life. You need to tell them how you're feeling. –Louise, MF Patient

How Common Is MF?

About 16,000 to 18,500 people in the United States are living with MF.

Graphic of the U.S. with text that says - About 16k-18.5k PEOPLE IN THE U.S. CURRENTLY have MF - 50+ MORE COMMON IN PEOPLE OVER 50Graphic of the U.S. with text that says - About 16k-18.5k PEOPLE IN THE U.S. CURRENTLY have MF - 50+ MORE COMMON IN PEOPLE OVER 50

Learn how myelofibrosis is diagnosed

How Is MF Managed?

To try to help control the signs and symptoms of MF, Healthcare Professionals use therapies such as blood transfusions, radiation, removal of the spleen, and stem cell transplantation. People with MF may be prescribed other treatments, including but not limited to chemotherapy drugs.

Get myelofibrosis resources and support.

What Is the Prognosis for People With MF?

Each individual journey with MF is unique, and how it may change over time can vary from person to person. It often develops slowly, which may allow some people to live with MF for years without symptoms. However, in other people it may worsen over time. Regular monitoring and medical supervision can help identify signs of disease progression and help minimize the risk of complications.

Factors that may be used to help Healthcare Professionals estimate survival can include:

  • Age
  • Symptom burden
  • Blood counts (including hemoglobin, white blood cells, and circulating blast cells)

Prognosis is based upon your individual risk level.

Your medical situation should be evaluated by your Healthcare Professional, who is the best source of information about life expectancy with MF.

Speak Up—and Spell Out How Your MF Makes You Feel

As you work together with your Healthcare Professional to understand and assess your condition, it’s important to be aware of how you feel and how MF affects your daily life, routines, and activity levels. Your symptoms, blood counts, and even your feelings can help you identify where you are on your journey with MF—and when it may be time to have a conversation with your MPN healthcare team.

Regularly evaluating your MF may help you recognize when something isn’t right. This can empower you to communicate with your Healthcare Professional about how your MF is affecting you and how it may be changing over time, so you can work together to manage your condition.

View helpful MF resources to help you get the conversation started



Learn how Marilyn’s essential thrombocythemia (ET) transformed to myelofibrosis (MF).

Image of two myelofibrosis awareness braclets

Receive Updates on Myelofibrosis

Get an MF awareness bracelet and educational resources when you register

Image of PDF - View Key Facts About Myelofibrosis (MF)

View Key Facts About Myelofibrosis

Get information to empower your journey with MF