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What Are Common MF Symptoms?

In addition to the symptoms caused by an enlarged spleen, myelofibrosis (MF) can affect the body in other ways. The table below lists common symptoms. Remember, you may have some of these symptoms but not others, as this condition is different for everyone.

fatigue icon

Are there activities that you were able to do 3 months ago that you struggle with now?

inactivity icon

How much does your inactivity influence your day-to-day activities?

Day or Night Sweats icon
Day or Night Sweats

Do you experience sweating, particularly at night or in the evenings? How often did this happen in the past month?

Itching icon

When you shower, do you ever feel itchy afterwards? How often?

Bone Pain icon
Bone Pain

Have you felt any deep achiness throughout your body that causes you to limit your activities?

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Unintentional Weight Loss

Are you losing weight, and if so, how much weight have you lost over the last 6 months?

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How often have you had a fever of >100 degrees Fahrenheit?

Cause of These Symptoms:

Inflammation caused by high levels of certain proteins (cytokines) in the blood

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Brain Fog

How often have you felt memory lapses, inability to pay attention for long periods, or having problems concentrating?

Cause of Symptom:

Having an MPN (PV, MF, or ET) is a recognized cause of concentration problems

abdominal Pain icon
Abdominal Pain or Discomfort

Do you have abdominal discomfort, particularly after eating?

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An Early Feeling of Fullness

Do you feel full quickly after meals?

Cause of These Symptoms:

Enlarged spleen (splenomegaly)

Additional symptoms you may experience include:

  • Bruising or bleeding easily
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According to the MPN Landmark Survey,* 81% of patients with MF reported that their symptoms reduced their quality of life.

*The MPN Landmark Survey was a web-based questionnaire, sponsored by Incyte, intended to help evaluate the patient disease burden in the MPN setting. A total of 813 patients in the US diagnosed with MF, PV, or ET completed the survey (207 with MF; 380 with PV; and 226 with ET).

Can MF Symptoms Vary or Change Over Time?

The more common symptoms of MF, such as tiredness (fatigue), itching, and night sweats, may come and go, or they may be more severe at certain times. Be sure to tell your Healthcare Professional about any and all symptoms you notice, even if you do not think they are related to MF.

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Since MF can progress over time, it is important to advocate for your own care by speaking up and spelling out how your MF symptoms affect you. Talk with your Healthcare Professional early on about your MF symptoms and how they affect your daily routines, activity levels, and overall quality of life. Let your Healthcare Professional know if there are activities you used to enjoy that you are no longer able to do.


Watch as physician assistant and medical liaison (MSL) at Incyte Amber Essenmacher reviews important topics that can help you talk with your Healthcare Professional about your MF.

Why Is Spleen Size Important in MF?

When the bone marrow cannot make enough normal blood cells, the spleen begins to make them. This causes the spleen to grow larger. An enlarged spleen is a common finding in MF. The medical term for an enlarged spleen is splenomegaly (splee-nuh-MEG-uh-lee).

What Are the Symptoms of an Enlarged Spleen?

Symptoms of an enlarged spleen can include

  • Pain or discomfort in the abdomen or under the left ribs
  • Feeling full when you haven’t eaten or have eaten very little

It is important to tell your Healthcare Professional if you have any of these symptoms.


Hear Amber Essenmacher, MPN expert and medical science liaison (MSL) at Incyte, explain why spleen size is important for people living with MF.

What Are Common Findings in MF?

The table below lists common findings in MF.



Enlarged spleen

Usually noticed by feeling the abdomen; can also be seen through procedures such as ultrasound, computed tomography, or MRI

Gene mutations: changes in genes associated with myelofibrosis

Blood tests

Scar-like tissue in the bone marrow (also called "fibrosis")

Bone marrow biopsy takes a sample of your bone marrow with a needle

Change in the form and number of white blood cells (WBCs), red blood cells (RBCs), and platelets

Blood is studied under a microscope to look at the shape of the blood cells and to see if abnormal blood cells are present. A complete blood count (CBC) and platelet count can be conducted to determine the number of various blood cells

What Should People With MF Know About Anemia?

With MF, scar tissue can build up in the bone marrow, preventing it from making enough red blood cells, resulting in anemia. Anemia is common in people living with MF. Anemia can be associated with certain symptoms that are important to monitor. If you’re experiencing anemia, be sure to discuss it with your Healthcare Professional.

Why Is Tracking MF Symptoms Important?

Because MF is a progressive condition, it has the potential to change over time. That means that some of the signs and symptoms may change as well. This is why it’s important to take an active role in monitoring your condition over time by tracking your MF on a regular basis—and sharing any changes with your Healthcare Professional.

Regular symptom tracking provides a number of valuable insights. Not only does it help identify trends within your health, but it can also help you and your Healthcare Professional better understand how to manage and adjust your care over time.

It is important to keep track of any symptoms you have, even if you are not sure they are related to your MF. Don’t assume that any symptom is too minor or not worth recording. Tracking and talking to your Healthcare Professional about your symptoms helps you both:

  • Understand how MF is affecting you
  • Follow how your MF is changing over time
  • Discuss options for managing your MF and its symptoms

Remember, these insights will help your Healthcare Professional understand what’s happening with your condition over time—and that can help ensure that your MF management approach is the right one for you.

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Use the MF Tracker

Track symptoms, blood counts, and blood transfusions related to MF


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Speak Up and Spell It Out

Learn why fine is not enough for your MPN journey