Sorry, you need to enable JavaScript to visit this website.

What Are the Signs & Symptoms of PV?

Polycythemia vera (PV) is a chronic blood cancer. This means it lasts a long time and may never go away. Some people with PV may not have symptoms. Others have severe symptoms that interfere with their daily lives. PV is also a progressive disease. This means that it may advance or get worse over time.

Icon of a stethoscope
It is important to talk to your Healthcare Professional about controlling your blood counts and disease-related symptoms. Knowing how PV is affecting you gives your Healthcare Professional important information to help manage your care.


Watch as physician assistant Amber Essenmacher reviews important topics that can help you talk with your Healthcare Professional about your myeloproliferative neoplasm (MPN).

What Are Common PV Symptoms?

Polycythemia vera (PV) symptoms include:

  • Tiredness (fatigue)
  • Itching (especially after a warm shower)
  • Headache
  • Sweating (at night or during the day)
  • Blurred vision or blind spots
  • Painful burning or numbness of the hands or feet
  • Bleeding from the gums and heavy bleeding from small cuts
  • Bone pain
  • Shortness of breath
  • Abdominal pain or discomfort
  • Early feeling of fullness when eating
  • Pain under the left ribs
  • Problems concentrating
  • Dizziness, vertigo, lightheadedness
  • Insomnia
  • Reddening of the face, or a burning feeling on the skin
  • Angina (chest pain)
  • Ringing in the ears

Why Is It Important to Track PV Symptoms?

Because PV is a progressive condition, it can change over time. That means that some of the signs and symptoms may change as well. This is why it’s important to take an active role in monitoring your PV over time. You can do this by tracking your condition on a regular basis.

Icon of a tracking
Careful symptom tracking provides a number of valuable insights. Not only does it help identify trends within your health, but it can also help you and your Healthcare Professional better understand how to manage and adjust your care over time.

It is important to keep track of any symptoms you have, even if you are not sure they are related to your condition. Don’t assume that any symptom is too minor or not worth recording. Tracking and talking to your Healthcare Professional about your symptoms helps you both:

  • Understand how PV is affecting you
  • Follow how your PV is changing over time
  • Discuss options for managing your PV and its symptoms

Remember, these insights will help your Healthcare Professional understand what's happening with your condition over time—and that can help ensure that your care management approach is the right one for you.

Icon of lines on a graph

Use the PV Tracker Tool Track symptoms, blood counts, and phlebotomies related to PV

What Are Complications From an Enlarged Spleen?

Your spleen helps your body fight infection and filter unwanted material, such as old or damaged blood cells. For a number of reasons, polycythemia vera can cause your spleen to grow and become bigger. An enlargement of the spleen is known as splenomegaly (splee-nuh-MEG-uh-lee). Symptoms of an enlarged spleen can include:

  • Pain or discomfort in your abdomen or under your left ribs
  • Feeling full when you haven’t eaten or have eaten very little
Icon of a spleen with text that says – BETWEEN 30% & 40% OF PATIENTS WITH PV PRESENT WITH AN ENLARGED SPLEENIcon of a spleen with text that says – BETWEEN 30% & 40% OF PATIENTS WITH PV PRESENT WITH AN ENLARGED SPLEEN

What Should I Know About Blood Counts and PV?

Hematocrit is a measure of the volume of red blood cells in the blood and is stated as a percentage. Signs that your PV is not being controlled can include a hematocrit level above 45%. Medical research suggests that an elevated hematocrit level can increase the risk of serious health problems, such as blood clots leading to heart attack or stroke.

Your Healthcare Professional may have a different hematocrit target for you based on your individual case, and may periodically order blood tests to monitor your condition. In addition to hematocrit, your Healthcare Professional may look at your red blood cell count, white blood cell count, and platelet count.

Keeping your blood counts—particularly your hematocrit—at the right levels is an important goal in managing your condition. Study findings have shown that for some patients, stabilizing blood counts can help lessen the chance of serious complications.

View a video with physician assistant Amber Essenmacher to better understand the relationship between blood counts and increased risk of health problems for people living with PV.

Icon of an open book

Questions About PV Disease Progression?

Read the blog article: When Polycythemia Vera Becomes Myelofibrosis